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Why do children under 9 receiving the influenza vaccine for the first time need two doses?

Question: 
Why do children under 9 receiving the influenza vaccine for the first time need two doses? 
 
Answer: 

Children under 9 years of age who have never had a seasonal influenza vaccine need 2 doses for best protection.  The first dose of the influenza vaccine “primes” the immune system but may not result in high levels of protection.  A second dose is needed to raise their level of protection. 

Date last reviewed: 
Thursday, Aug 18, 2022